What does the combining form "estr/o" specifically signify?

The combining form "estr/o" specifically signifies "female." This term is derived from the word estrogen, a significant hormone associated with the female reproductive system. Estrogen plays a crucial role in the development of female secondary sexual characteristics and the regulation of various physiological functions related to the female reproductive cycle. The presence of "estr/o" in medical terminology commonly relates to female biology, reproductive health, and conditions uniquely associated with women. Therefore, understanding this combining form is essential for grasping related medical and anatomical concepts in the context of female health.